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Category Archives: Disease Categories
Acute Flaccid Myelitis and Enterovirus D68
Background Enteroviruses, which may cause gastroenteritis or upper respiratory tract infections, are well-known to have neurotropism – a predilection in a proportion of individuals to spread to certain types of neurones, thereby resulting in characteristic neurological syndromes that occur after … Continue reading
Journal Club Review: “Cerebral Amyloid Angiopathy with and without Haemorrhage
Background Sporadic cerebral amyloid angiopathy (CAA) is the most common cause of lobar intracranial haemorrhage, which in itself accounts for about 5-10% of all strokes. Amyloid deposition in small arteries of the cerebrum leads to friability and haemorrhage. There are also … Continue reading
Posted in Disease Categories, Stroke
Tagged brain haemorrhage, cerebral amyloid angiopathy, stroke
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Journal Club Review “Certainty of Stroke Diagnosis: Incremental Benefit with CT Perfusion over Non-Contrast CT and CT Angiography”
Background The accompanying primer, Thrombolysis for Stroke and role of CT perfusion Imaging, describes the difficulties and potential shortcomings of thrombolysis for acute stroke and the way that CT perfusion may improve patient selection for thrombolysis. This paper, by Hopyat … Continue reading
Posted in Stroke
Tagged CT angiography, CT perfusion, stroke, stroke diagnosis, stroke imaging, stroke mimics, thrombolysis, TIA, unenhanced CT
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Primer on Thrombolysis for Stroke and Role of CT Perfusion Imaging
Stroke, defined as a sudden vascular event resulting in localised brain damage (World Health Organisation, 1978), is without doubt a major challenge in health care, being the third most common cause of mortality in developed countries and the single greatest … Continue reading
Posted in Primer Posts for General Readers, Stroke
Tagged CT perfusion, stroke, stroke diagnosis, stroke imaging, thrombolysis
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Journal Club Review: Cervical Vertigo
Background Cervical pain from spondylosis or muscular problems is a very common symptom in the general adult population, estimated in a recent study to have a point prevalence of 4.9% and a global burden of 33.6 million disability-adjusted life years … Continue reading
Journal Club Review: Driving after a Single Seizure
Background One of the main issues facing a patient diagnosed as having had a first epileptic seizure without any sinister underlying lesion – often a young adult and otherwise well – is the driving ban. One can only be sympathetic … Continue reading
Journal Club Commentary: Management of Single Seizures
Introduction For this edition of the Neurology Online Journal Club I wanted to review not one but a series of papers to address a specific issue, namely predicting the risk of seizure recurrence after a single seizure and predicting how … Continue reading
Journal Club Scientific Review: Structural Brain Changes in Migraine (the CAMERA-2 Study)
Scientific Review For this paper, I decided to complete two complementary reviews. The Journal Club General Reader Review can be considered a background and a summary for this scientific review. Background It has been suggested for some time that, for a … Continue reading
Journal Club General Reader Review: Structural Brain Changes in Migraine (the CAMERA-2 Study)
Review for General Readers For this paper, I decided to complete two complementary reviews. This one for general readers can be considered a background and a summary for the Journal Club Scientific Review. Background For some time there has been a … Continue reading
Journal Club review: Risk Factors in Critical Illness Myopathy during the early course of Critical Illness – a Prospective Observational Study
Summary for General Readers As discussed in the accompanying primer, I chose to review a research article (Weber-Carstens et al., 2010) I found that looked both at risk factors for development of critical illness myopathy and a new diagnostic test for … Continue reading
Neurology Online Journal Club 