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Author Archives: dulcetware
Inhaled Levodopa
Introduction Levodopa was the first main, and arguably still the best, treatment for Parkinson’s disease. Being similar in structure to tyrosine, it is absorbed through the gut by an amino acid transporter – its half life in the blood is … Continue reading
Posted in Parkinson's Disease, Uncategorized
Tagged inhaled levodopa, L-DOPA, Parkinson Disease
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Revolution in acute ischaemic stroke care: a practical guide to mechanical thrombectomy
Introduction Stroke is the most common cause of disability in Western Countries, and its lifetime risk is up to 25%. While managing acute stroke patients in hyperacute stroke units is regarded as having benefits for short and long term outcome, … Continue reading
Posted in Uncategorized
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Testing for COVID-19 Infection
Accurate testing for SARS-CoV-2 infection, by which we mean testing with few false positives as well as few false negatives, is important not only for clinical management of individual cases but for epidemiological case tracing, limiting spread of infection and … Continue reading
Distinguishing Encephalitis from Encephalopathy
Encephalitis may be defined as infection or inflammation of the brain substance, resulting typically in disturbed sensorium and perhaps seizures or focal neurological deficits and sometimes pyrexia. Encephalopathy in the other hand represents disturbed sensorium not due to an infective … Continue reading
Making a Differential Diagnosis using a Clinical Database
Background A great deal of time is spent in medicine reading and writing case reports. Essentially, clinical features are listed and a diagnosis made. Excluding those cases that point to a novel means of treatment, a case report is often … Continue reading
Posted in Genetics
Tagged differential diagnosis, Human Phenotype Ontology, OMIM, Orphanet
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Coronavirus
Coronavirus is obviously not a neurological disease, apart from an isolated case report of encephalitis associated with the condition, which is to be expected very rarely in association with viral infections, but because it is so topical this paper Clinical … Continue reading
Anticonvulsant Medications for Status Epilepticus
Status epilepticus is a medical emergency with significant morbidity and mortality and, in circumstances where benzodiazepines alone have failed to terminate seizures, has traditionally been treated with anticonvulsants such as phenytoin or phenobarbitone. Other intravenously administered antiepileptics have also been … Continue reading
Posted in Epilepsy, Intensive Care Neurology
Tagged Epilepsy, fosphenytoin, levetiracetam, phenytoin, Statistics, status epilepticus, valproate
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Galcanezumab in Chronic Migraine
Migraine is one of the most common neurological conditions, and chronic migraine is a condition that, while less common than episodic migraine, is nevertheless a major cause of loss of quality of life in otherwise well individuals. Once analgesia headache … Continue reading
Neurology Online Journal Club 