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Recent Posts
- Anticonvulsant Medications for Status Epilepticus
- Galcanezumab in Chronic Migraine
- Disease Modifying Therapies in Multiple Sclerosis: Background for General Readers
- Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis
- Detection of Brain Activation in Vegetative State by Standard Electroencephalography
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Anticonvulsant Medications for Status Epilepticus
Status epilepticus is a medical emergency with significant morbidity and mortality and, in circumstances where benzodiazepines alone have failed to terminate seizures, has traditionally been treated with anticonvulsants such as phenytoin or phenobarbitone. Other intravenously administered antiepileptics have also been … Continue reading
Posted in Epilepsy, Intensive Care Neurology
Tagged Epilepsy, fosphenytoin, levetiracetam, phenytoin, Statistics, status epilepticus, valproate
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Galcanezumab in Chronic Migraine
Migraine is one of the most common neurological conditions, and chronic migraine is a condition that, while less common than episodic migraine, is nevertheless a major cause of loss of quality of life in otherwise well individuals. Once analgesia headache … Continue reading
Detection of Brain Activation in Vegetative State by Standard Electroencephalography
This paper by Claassen et al., 2019 looks at EEG pattern changes in response to verbally given movement commands to see if there is a subset of vegetative state patients who are cognitively responsive and yet who have no motor … Continue reading
Double-Blind Double-Dummy Randomised Study of Continuous Intrajejunal infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease
Background Levodopa, a pro-drug of dopamine, has been used successfully to treat symptoms of Parkinson’s disease for fifty years and remains the mainstay of medical management. However after years of treatment, with increasing loss of dopaminergic presynaptic terminals, symptomatic control … Continue reading
Mechanical Thrombectomy for Ischaemic Stroke
Introduction Stroke is the most common cause of disability in Western Countries, and its lifetime risk is 1 in 6 for men and 1 in 5 for women. While managing acute stroke patients in hyperacute stroke units overall has … Continue reading
Posted in Stroke
Tagged Statistics, stroke, Stroke treatment, Thrombectomy, thrombolysis
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Thymectomy for Myasthenia Gravis
Introduction While thymectomy has long been considered an option to treat myasthenia even if there is simply thymic tissue present rather than thymoma or thymic carcinoma, it has been uncertain how much benefit is achieved by undergoing this major … Continue reading
Safinamide in Parkinson’s Disease
Background The rather specific dopaminergic deficit in Parkinson’s disease (PD) has meant that dopaminergic replacement medications have proven to be an effective mainstay of treatment of the condition. However, later on in the course of the disease, such treatment … Continue reading
Posted in Parkinson's Disease
Tagged Dopamine, Dyskinesia, Parkinson Disease, Safinamide
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Anti K+ Channel Antibodies in Neuromyotonia
Background At this Journal Club it was decided to review a historical paper on the pathophysiology underlying autoimmune neuromyotonia. The paper, “Autoantibodies Detected to Expressed K+ Channels Are Implicated in Neuromyotonia”, from Annals of Neurology (1997, 41:238-246), used a novel … Continue reading
Posted in Inflammatory/ Auto-Immune Diseases
Tagged Antibody Assay, Autoimmune, Immunology, Neuromytonia
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