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Category Archives: Disease Categories
Testing for COVID-19 Infection
Accurate testing for SARS-CoV-2 infection, by which we mean testing with few false positives as well as few false negatives, is important not only for clinical management of individual cases but for epidemiological case tracing, limiting spread of infection and … Continue reading
Distinguishing Encephalitis from Encephalopathy
Encephalitis may be defined as infection or inflammation of the brain substance, resulting typically in disturbed sensorium and perhaps seizures or focal neurological deficits and sometimes pyrexia. Encephalopathy in the other hand represents disturbed sensorium not due to an infective … Continue reading
Making a Differential Diagnosis using a Clinical Database
Background A great deal of time is spent in medicine reading and writing case reports. Essentially, clinical features are listed and a diagnosis made. Excluding those cases that point to a novel means of treatment, a case report is often … Continue reading
Posted in Genetics
Tagged differential diagnosis, Human Phenotype Ontology, OMIM, Orphanet
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Coronavirus
Coronavirus is obviously not a neurological disease, apart from an isolated case report of encephalitis associated with the condition, which is to be expected very rarely in association with viral infections, but because it is so topical this paper Clinical … Continue reading
Anticonvulsant Medications for Status Epilepticus
Status epilepticus is a medical emergency with significant morbidity and mortality and, in circumstances where benzodiazepines alone have failed to terminate seizures, has traditionally been treated with anticonvulsants such as phenytoin or phenobarbitone. Other intravenously administered antiepileptics have also been … Continue reading
Posted in Epilepsy, Intensive Care Neurology
Tagged Epilepsy, fosphenytoin, levetiracetam, phenytoin, Statistics, status epilepticus, valproate
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Galcanezumab in Chronic Migraine
Migraine is one of the most common neurological conditions, and chronic migraine is a condition that, while less common than episodic migraine, is nevertheless a major cause of loss of quality of life in otherwise well individuals. Once analgesia headache … Continue reading
Detection of Brain Activation in Vegetative State by Standard Electroencephalography
This paper by Claassen et al., 2019 looks at EEG pattern changes in response to verbally given movement commands to see if there is a subset of vegetative state patients who are cognitively responsive and yet who have no motor … Continue reading
Double-Blind Double-Dummy Randomised Study of Continuous Intrajejunal infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease
Background Levodopa, a pro-drug of dopamine, has been used successfully to treat symptoms of Parkinson’s disease for fifty years and remains the mainstay of medical management. However after years of treatment, with increasing loss of dopaminergic presynaptic terminals, symptomatic control … Continue reading
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