Category Archives: Disease Categories

Different disease categories under which various journal reviews fall

Distinguishing Encephalitis from Encephalopathy

Encephalitis may be defined as infection or inflammation of the brain substance, resulting typically in disturbed sensorium and perhaps seizures or focal neurological deficits and sometimes pyrexia. Encephalopathy in the other hand represents disturbed sensorium not due to an infective … Continue reading

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Making a Differential Diagnosis using a Clinical Database

Background A great deal of time is spent in medicine reading and writing case reports. Essentially, clinical features are listed and a diagnosis made. Excluding those cases that point to a novel means of treatment, a case report is often … Continue reading

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Coronavirus

Coronavirus is obviously not a neurological disease, apart from an isolated case report of encephalitis associated with the condition, which is to be expected very rarely in association with viral infections, but because it is so topical this paper Clinical … Continue reading

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Anticonvulsant Medications for Status Epilepticus

Status epilepticus is a medical emergency with significant morbidity and mortality and, in circumstances where benzodiazepines alone have failed to terminate seizures, has traditionally been treated with anticonvulsants such as phenytoin or phenobarbitone. Other intravenously administered antiepileptics have also been … Continue reading

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Galcanezumab in Chronic Migraine

Migraine is one of the most common neurological conditions, and chronic migraine is a condition that, while less common than episodic migraine, is nevertheless a major cause of loss of quality of life in otherwise well individuals. Once analgesia headache … Continue reading

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Disease Modifying Therapies in Multiple Sclerosis: Background for General Readers

Multiple sclerosis (MS) is a presumed autoimmune condition of demyelination and often inflammation of the central nervous system. Its evolution is very variable; some patients suffer episodes lasting weeks to months with complete or near complete recovery in between, and … Continue reading

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Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

Recent studies indicate that higher strength disease modifying therapies (DMTs) may slow disability progression in secondary progressive multiple sclerosis (MS), as well as reduce the number of relapses. There have also been trials in primary progressive MS but these, most … Continue reading

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Detection of Brain Activation in Vegetative State by Standard Electroencephalography

This paper by Claassen et al., 2019 looks at EEG pattern changes in response to verbally given movement commands to see if there is a subset of vegetative state patients who are cognitively responsive and yet who have no motor … Continue reading

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Double-Blind Double-Dummy Randomised Study of Continuous Intrajejunal infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease

Background Levodopa, a pro-drug of dopamine, has been used successfully to treat symptoms of Parkinson’s disease for fifty years and remains the mainstay of medical management. However after years of treatment, with increasing loss of dopaminergic presynaptic terminals, symptomatic control … Continue reading

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Mechanical Thrombectomy for Ischaemic Stroke

  Introduction Stroke is the most common cause of disability in Western Countries, and its lifetime risk is 1 in 6 for men and 1 in 5 for women. While managing acute stroke patients in hyperacute stroke units overall has … Continue reading

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