Category Archives: Parkinson’s Disease

Inhaled Levodopa

Posted on March 24, 2023 by dulcetware

Introduction Levodopa was the first main, and arguably still the best, treatment for Parkinson’s disease. Being similar in structure to tyrosine, it is absorbed through the gut by an amino acid transporter – its half life in the blood is … Continue reading →

Posted in Parkinson's Disease, Uncategorized | Tagged , , | Leave a comment

Double-Blind Double-Dummy Randomised Study of Continuous Intrajejunal infusion of Levodopa-Carbidopa Intestinal Gel in Advanced Parkinson’s Disease

Posted on February 8, 2019 by dulcetware

Background Levodopa, a pro-drug of dopamine, has been used successfully to treat symptoms of Parkinson’s disease for fifty years and remains the mainstay of medical management. However after years of treatment, with increasing loss of dopaminergic presynaptic terminals, symptomatic control … Continue reading →

Posted in Parkinson's Disease | Tagged , , , | Leave a comment

Safinamide in Parkinson’s Disease

Posted on September 6, 2016 by dulcetware

  Background The rather specific dopaminergic deficit in Parkinson’s disease (PD) has meant that dopaminergic replacement medications have proven to be an effective mainstay of treatment of the condition. However, later on in the course of the disease, such treatment … Continue reading →

Posted in Parkinson's Disease | Tagged , , , | Leave a comment

Clinical Features and Pathology of “Parkinson’s Plus” Syndromes

Posted on August 3, 2015 by dulcetware

Background It has long been known that there exist variants of Parkinson’s disease (PD), loosely and perhaps inaccurately described as PD plus syndromes, that may carry features of Parkinsonism but which also have other clinical features. Such conditions have distinct … Continue reading →

Posted in Parkinson's Disease | Tagged , , , , | Leave a comment

Journal Club Review: A Double-Blind, Delayed-Start Trial of Rasagiline in Parkinson’s Disease

Posted on January 12, 2013 by dulcetware

Summary for General Readers Given it was first introduced to treat Parkinson’s disease in the 1960’s (see the accompanying background information on Parkinson’s disease for general readers), it is surprising that it was not until four decades later that a major … Continue reading →

Posted in Parkinson's Disease | Tagged , , , | Leave a comment

Primer on Parkinson’s Disease for General Readers

Posted on January 8, 2013 by dulcetware

Pathology Parkinson’s Disease (PD) is a relatively common condition affecting around 1% of all individuals aged over 60, and increasing towards 5% of those over 80. It is characterised by neurodegeneration, a “wearing out” of certain groups of nerve cells … Continue reading →

Posted in Parkinson's Disease, Primer Posts for General Readers | Tagged , , | 2 Comments