Author Archives: dulcetware

About dulcetware

designing educational software applications

Myasthenia Gravis: Subgroup Classification and Therapeutic Strategies

Background Myasthenia gravis (MG) is a neurological condition characterised by a fatiguing weakness of certain muscle groups, particularly those that control eye opening, eye movements, speech and swallowing When severe the proximal muscles of the limbs and respiratory muscles may … Continue reading

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Clinical Features and Pathology of “Parkinson’s Plus” Syndromes

Background It has long been known that there exist variants of Parkinson’s disease (PD), loosely and perhaps inaccurately described as PD plus syndromes, that may carry features of Parkinsonism but which also have other clinical features. Such conditions have distinct … Continue reading

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Acute Flaccid Myelitis and Enterovirus D68

Background Enteroviruses, which may cause gastroenteritis or upper respiratory tract infections, are well-known to have neurotropism – a predilection in a proportion of individuals to spread to certain types of neurones, thereby resulting in characteristic neurological syndromes that occur after … Continue reading

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Journal Club Review: “Cerebral Amyloid Angiopathy with and without Haemorrhage

Background Sporadic cerebral amyloid angiopathy (CAA) is the most common cause of lobar intracranial haemorrhage, which in itself accounts for about 5-10% of all strokes. Amyloid deposition in small arteries of the cerebrum leads to friability and haemorrhage. There are also … Continue reading

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Journal Club Review “Certainty of Stroke Diagnosis: Incremental Benefit with CT Perfusion over Non-Contrast CT and CT Angiography”

Background The accompanying primer,  Thrombolysis for Stroke and role of CT perfusion Imaging, describes the difficulties and potential shortcomings of thrombolysis for acute stroke and the way that CT perfusion may improve patient selection for thrombolysis. This paper, by Hopyat … Continue reading

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Primer on Thrombolysis for Stroke and Role of CT Perfusion Imaging

Stroke, defined as a sudden vascular event resulting in localised brain damage (World Health Organisation, 1978), is without doubt a major challenge in health care, being the third most common cause of mortality in developed countries and the single greatest … Continue reading

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Journal Club Review: Cervical Vertigo

Background Cervical pain from spondylosis or muscular problems is a very common symptom in the general adult population, estimated in a recent study to have a point prevalence of 4.9% and a global burden of 33.6 million disability-adjusted life years … Continue reading

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Journal Club Review: Driving after a Single Seizure

Background One of the main issues facing a patient diagnosed as having had a first epileptic seizure without any sinister underlying lesion – often a young adult and otherwise well – is the driving ban. One can only be sympathetic … Continue reading

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Journal Club Commentary: Management of Single Seizures

Introduction For this edition of the Neurology Online Journal Club I wanted to review not one but a series of papers to address a specific issue, namely predicting the risk of seizure recurrence after a single seizure and predicting how … Continue reading

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Primer on Statistics for Non-Statisticians

Many of the journals discussed assume a knowledge of statistics. In fact, it is often the statistics that are the crucial issue in a critical review of a research study. And paradoxically it seems that the further we move from the more … Continue reading

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