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Author Archives: dulcetware
Anti K+ Channel Antibodies in Neuromyotonia
Background At this Journal Club it was decided to review a historical paper on the pathophysiology underlying autoimmune neuromyotonia. The paper, “Autoantibodies Detected to Expressed K+ Channels Are Implicated in Neuromyotonia”, from Annals of Neurology (1997, 41:238-246), used a novel … Continue reading
Posted in Inflammatory/ Auto-Immune Diseases
Tagged Antibody Assay, Autoimmune, Immunology, Neuromytonia
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Comparison of New Oral Anticoagulants (NOACs) with Warfarin
Background Ischaemic stroke is typically either thrombotic (clotting within a cerebral vessel) or embolic (passage of clot material from a more proximal vessel to become lodged in a cerebral vessel). A proportion of embolic stroke events will arise from arterial … Continue reading
Posted in Stroke
Tagged anticoagulation, brain haemorrhage, NOAC, stroke, TIA, warfarin
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Varicella Zoster is the Cause of Giant Cell Arteritis
Background Giant cell arteritis is an inflammatory condition of certain blood vessels that presents in the elderly. Those vessels affected include the: temporal artery resulting in headache and scalp tenderness over the inflamed artery, ciliary artery resulting in ischaemic optic … Continue reading
Posted in Infectious Diseases
Tagged giant cell arteritis, Headache, shingles, temporal artery, varicella zoster
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Myasthenia Gravis: Subgroup Classification and Therapeutic Strategies
Background Myasthenia gravis (MG) is a neurological condition characterised by a fatiguing weakness of certain muscle groups, particularly those that control eye opening, eye movements, speech and swallowing When severe the proximal muscles of the limbs and respiratory muscles may … Continue reading
Posted in Myasthenia
Tagged Autoantibodies, Evidence based treatment, Myasthenia gravis, Myasthenic crisis
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Clinical Features and Pathology of “Parkinson’s Plus” Syndromes
Background It has long been known that there exist variants of Parkinson’s disease (PD), loosely and perhaps inaccurately described as PD plus syndromes, that may carry features of Parkinsonism but which also have other clinical features. Such conditions have distinct … Continue reading
Acute Flaccid Myelitis and Enterovirus D68
Background Enteroviruses, which may cause gastroenteritis or upper respiratory tract infections, are well-known to have neurotropism – a predilection in a proportion of individuals to spread to certain types of neurones, thereby resulting in characteristic neurological syndromes that occur after … Continue reading
Journal Club Review: “Cerebral Amyloid Angiopathy with and without Haemorrhage
Background Sporadic cerebral amyloid angiopathy (CAA) is the most common cause of lobar intracranial haemorrhage, which in itself accounts for about 5-10% of all strokes. Amyloid deposition in small arteries of the cerebrum leads to friability and haemorrhage. There are also … Continue reading
Posted in Disease Categories, Stroke
Tagged brain haemorrhage, cerebral amyloid angiopathy, stroke
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Journal Club Review “Certainty of Stroke Diagnosis: Incremental Benefit with CT Perfusion over Non-Contrast CT and CT Angiography”
Background The accompanying primer, Thrombolysis for Stroke and role of CT perfusion Imaging, describes the difficulties and potential shortcomings of thrombolysis for acute stroke and the way that CT perfusion may improve patient selection for thrombolysis. This paper, by Hopyat … Continue reading
Posted in Stroke
Tagged CT angiography, CT perfusion, stroke, stroke diagnosis, stroke imaging, stroke mimics, thrombolysis, TIA, unenhanced CT
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Primer on Thrombolysis for Stroke and Role of CT Perfusion Imaging
Stroke, defined as a sudden vascular event resulting in localised brain damage (World Health Organisation, 1978), is without doubt a major challenge in health care, being the third most common cause of mortality in developed countries and the single greatest … Continue reading
Posted in Primer Posts for General Readers, Stroke
Tagged CT perfusion, stroke, stroke diagnosis, stroke imaging, thrombolysis
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Journal Club Review: Cervical Vertigo
Background Cervical pain from spondylosis or muscular problems is a very common symptom in the general adult population, estimated in a recent study to have a point prevalence of 4.9% and a global burden of 33.6 million disability-adjusted life years … Continue reading
